Molecular Therapy for Muscular Dystrophy
Organized by Teruo Shimizu and Ryoichi MatsudaSponsored by Muscular Dystrophy Group, The Ministry of Health, Labour and Welfare, Japan
November 26 (Tuesday) through November 27 (Wednesday), 2002.
Place: Gakushi-Kaikan
3-28 Kanda Nishiki-cho, Chiyoda-ku, Tokyo 101-8459, Japan
Phone# +81-3-3292-5936 http://www.gakushikai.or.jp/facilities/index.html
Program
November 26 (Tuesday), 2002
Chairpersons: Drs. Teruo Shimizu and Ryoichi Matsuda
9:30 Teruo Shimizu
(Department of Neurology and Neuroscience, Teikyo University School of Medicine, Tokyo 173-8605, Japan)
Opening remarks
9:45 Richard C. Strohman
(Department of Molecular and Cell Biology, Univ. of California, Berkeley, CA 94720-3206, USA)
Modern biology & medicine in crisis: Difficulties in, and new solutions to, understanding the origins of disease phenotype
10:30 H. Lee Sweeney
(Department of Physiology, University of Pennsylvania, Philadelphia, PA19104, USA)
Stop codon suppression for treatment of a subset of dystrophin mutations
11:30 Ryoichi Matsuda
(Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan)
Negamycin can restore dystrophin in mdx muscles
12:15 Lunch
Chairpersons: Drs. Paul L. McNeil and Shigeo Ohta
14:00 Valerie Allamand
(INSERM U523, Institut de Myologie-Bâtiment Joseph Babinski, Groupe Hospitalier Pitié-Salpétrière, 75651 Paris Cedex 13, France)
Ex vivo treatment of laminin alpha 2 chain-deficient myotubes with antibiotics forcing readthrough of premature stop codons
14:45 Elisabeth Barton
(Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA)
Systemic administration of L-arginine benefits skeletal muscle function in mdx mice
15:30 Coffee break
Chairpersons: Drs. Terrence Partridge and Shoichi Ishiura
16:00 Yoshihiro Kashiwaya
(Unit of Metabolic Control Laboratory of Membrane biology and biophysics/National Institutes of Alcohol abuse and Alcoholism /National Institutes of Health/Department of Health and Human Services, Rockville, MD 20852, USA)
To be announced
16:45 Shigeo Ohta
(Department of Biochemistry and Cell Biology, Institute of Gerontology, Nippon Medical School, Kanagawa, Japan)
Protein therapeutics by using the super anti-apoptosis factor FNK
17:30 Paul L. McNeil
(Department of Anatomy and Cellular Biology and Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912-2000, USA)
How cells repair plasma membrane disruptions
18:30 Social hour
November 27 (Wednesday), 2002
Chairpersons: Drs. H. Lee Sweeney and Masafumi Matsuo
9:30 Ugo Carraro
(C.N.R. Institute of Neuroscience, Unit for Muscle Biology and Physiopathology, c/o Department of Biomedical Sciences, Padua Medical School, University of Padua, Italy)
Basics to gene therapy: Stage and quantify cell death and myogenesis in muscular dystrophies
10:15 Naohiro Hashimoto
(Stem Cell Research Unit, Mitsubishi Kagaku Institute of Life Sciences, Tokyo 194-8511, Japan)
Plasticity of muscle stem cells
11:00 Shin'ichi Takeda
(Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187-8502, Japan)
New therapeutic approaches to dystrophin-deficient muscular dystrophy: Over-expression of endogenous utrophin
11:45 Lunch
Chairpersons: Drs. Ugo Carraro and Kiichiro Matsumura
13:00 Terence Partridge
(Muscle Cell Biology Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, W12 0NN, UK)
Behavior of satellite cells in regenerating muscle
And
Correction of the mutated dystrophin gene by casual and deliberate exon skipping
14:00 Masafumi Matsuo
(Division of Molecular Medicine, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan)
Treatment of Duchenne muscular dystrophy with oligonucleotides against an exonic splicing enhancer sequence
14:45 Tatsushi Toda
(Division of Functional Genomics, Department Post-Genomics and Diseases, Osaka University Graduate School of Medicine, Osaka565-0871, Japan)
Recent advances in Fukuyama CMD and muscle-eye-brain disease
15:30 Coffee break
Chairpersons: Drs. Elisabeth Barton and Shin'ichi Takeda
16:00 Shoichi Ishiura
(Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan)
Direct evidence that RNA-binding proteins interact with CUG tri- and CCUG tetra-nucleotide repeats in myotonic dystrophy: its therapeutic implications
16:45 Kiichiro Matsumura (Department of Neurology and Neuroscience,Teikyo University School of Medicine,Tokyo 173-8605, Japan)
Disruption of dystroglycan axis by matrix metalloproteinase in cardiomyopathic hamster muscle
17:30 Ryoichi Matsuda
(Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902, Japan)
Closing remarks
Ryoichi Matsuda, D. Sci.
Dept. of Life Sci.,
The Univ. of Tokyo at Komaba.
3-8-1 Komaba, Meguro-ku, Tokyo 153-8902
Japan
Phone# +81-3-5454-6637,-6636
Fax# +81-3-5454-4306
e-mail; ryoichi@matsuda.c.u-tokyo.ac.jp