ALUMINUM

<BODY TEXT="#000000" LINK="#0000ff" VLINK="#df0070" BACKGROUND="5.gif"> <CENTER> <IMG SRC="newtxt9.gif" WIDTH="706" HEIGHT="34"> <P> <BR> <P> <TABLE CELLPADDING="2"> <TR> <TD><IMG SRC="cnr3.gif" WIDTH="135" HEIGHT="135" ALIGN="Middle" BORDER="0"></TD> <TD>           </TD> <TD><IMG SRC="zatta.gif" WIDTH="130" HEIGHT="165" ALIGN="Top"></TD> <TD>             </TD> <TD><IMG SRC="al3.gif" WIDTH="135" HEIGHT="135" ALIGN="Middle" BORDER="0"></TD> </TR> <TR> <TD></TD> <TD></TD> <TD><P ALIGN=Center> <B>Prof. Paolo Zatta</B></TD> <TD></TD> <TD></TD> </TR> </TABLE> </CENTER> <CENTER> <P ALIGN=Center> <FONT COLOR="Blue"><FONT size=6>CNR National Research Council of Italy<BR> CNR Center on Metalloproteins<BR> University of Padova<BR> Department of Biology<BR> Via G. Colombo 3, 35121 Padova, Italy<BR> Fax +39 049 8276330<BR> Tel +39 049 8276331<BR> </FONT></FONT> <P ALIGN=Left> An International Aluminum Network was established in 1995 open to all scientists interested to a better understanding of the aluminum impact on biological systems from different point of views: Physiological, Pathological, Toxicological, Biochemical in humans as well as in vitro and in vivo experimentation. <P ALIGN=Left> This network is devoted to exchanging proposals and scientific data (relevant papers, experimental data etc.) as well as to inform on various activities around the world: workshops, round tables, symposia etc. where relevant issues on Chemistry or Biology related to the Physiopathology of aluminum could be discussed. <P ALIGN=Left> Besides, being the most abundant metal and the third most abundant element on the Earth's crust, aluminum has been implicated as an etiological factor in some pathologies related to long-term dialysis treatment of uremic patients and as a potential factor or cofactor in the Alzheimer's syndrome, as well as in the etiopathogenesis of other neurodegenerative diseases, Parkinsonism, Amyotrophic Lateral Sclerosis and other diseases. <P ALIGN=Left> <TABLE CELLPADDING="2"> <TR> <TD><IMG SRC="books.gif" WIDTH="34" HEIGHT="34" ALIGN="Middle"></TD> <TD><P ALIGN=Left> To update this complex matter our group has recently edited several books with the aim to critically ordering an enormous mass of information. These are the most recent titles available.</TD> </TR> </TABLE> <P> <TABLE CELLPADDING="2"> <TR> <TD><IMG SRC="nw1.gif" WIDTH="125" HEIGHT="175" ALIGN="Middle" BORDER="0"></TD> <TD><FONT COLOR="Red"><B>Aluminum in Chemistry, Biology and Medicine</B></FONT> (1991) Nicolini M., Zatta P.F., Corain B., eds., <I>Raven Press</I>, New York, Cortina Intern., Verona. pp. 117.</TD> </TR> </TABLE> <P> <TABLE CELLPADDING="2"> <TR> <TD><FONT COLOR="Red"><B>Aluminum in Chemistry, Biology and Medicine; Clinical, Cellular, Molecular and Analytical Aspects of Aluminopathies</B></FONT>(1994) Nicolini M., Zatta P., Corain B., guest eds., <I>Life Chem. Reports </I>(Special issue) Vol. 11, pp. 270.</TD> <TD><IMG SRC="nw2.gif" WIDTH="125" HEIGHT="175" BORDER="0" ALIGN="Middle"></TD> </TR> </TABLE> <P> <TABLE CELLPADDING="2"> <TR> <TD><IMG SRC="nw3.gif" WIDTH="125" HEIGHT="175" BORDER="0" ALIGN="Middle"></TD> <TD><FONT COLOR="Red"><B>Non-Neuronal Cells in Alzheimer's Disease</B></FONT>(1995)     Zatta P. and Nicolini M., eds., <I>World Scientific Publ.</I>, Singapore, London. pp. 232.</TD> </TR> </TABLE> <P> </CENTER> <P> <B>PROJECTS OF OUR LAB IN PADOVA:</B> <UL> <LI> Al(III)speciation and biological effects in <I>in vivo </I>and  <I>in vitro</I> models <LI> Al(III) as a modifier of blood-brain barrier permeability <LI> Al(IIII) and hyper-phosphorylation in neuronal cells <LI> Al(III) in cell membrane dismetabolism in ageing and in neurological diseases <LI> Al(III) in renal failure related pathologies <LI> Al(III) and neuritogenesis <LI> Al(III) and Ca<SUP>2+</SUP> dismetabolism <LI> Al(III) as a pro-oxidant in free radicals production </UL> <P> <B><A HREF="collab.htm" TARGET="_top">Collaborations</A></B> <P> <B><A HREF="public.htm" TARGET="_top">Recent publications</A></B> <P> <B><A HREF="brain.htm" TARGET="_top">Brain Bank</A></B> <TABLE BORDER=0 cellspacing=20 WIDTH=60%> <TR> <TD><A HREF="ospiti.htm" TARGET="_top"><IMG SRC="pallino.gif" border=0> </A></TD> <TD align=left><A HREF="ospiti.htm" TARGET="_top"><A HREF="ospiti.htm" TARGET="_top"><FONT size=5> <B>RELEVANT ISSUES ON ALUMINUM</B></FONT></A></A></TD> </TR> <TR> <TD><A HREF="news.htm" TARGET="_top"><IMG SRC="pallino.gif" border=0 align=center hspace=1></A></TD> <TD align=left><A HREF="news.htm" TARGET="_top"><A HREF="news.htm" TARGET="_top"><FONT size=5> <B>WHAT'S NEW</B></FONT></A></A></TD> </TR> </TABLE> <P> <BR> <A HREF="mailto:zatta@civ.bio.unipd.it"><IMG src="mail.gif" border=0 align=left></A> <BLOCKQUOTE> If you wish to contact Prof. Zatta, please mail to <A HREF="mailto:zatta@civ.bio.unipd.it"> zatta@civ.bio.unipd.it</A><BR> Comments and suggestions are welcome. </BLOCKQUOTE> <P> <HR> THIS PAGE REFERENCES:<BR> © 1996 <A href="http://www.bio.unipd.it/">BioPD</A> - University of Padova - Centro CNR Metalloproteine - Author: Daniele Cervellin <BR> Mail to: <A HREF="mailto:cervelin@civ.bio.unipd.it">cervelin@civ.bio.unipd.it</A> - Last Revision: <I>November, 20, 1998</I><BR> Tested on <I>Explorer 3.0</I> <HR> <P> </BODY>