Primary Research Publications
2024 |
Bastianello G, Kidiyoor GR, Lowndes C, Li Q, Bonnal R, Godwin J, Iannelli F, Drufuca L, Bason R, Orsenigo F, Parazzoli D, Pavani M, Cancila V, Piccolo S, Scita G, Ciliberto A, Tripodo C, Pagani M, Foiani M. Mechanical stress during confined migration causes aberrant mitoses and c- MYC amplification. Proc Natl Acad Sci U S A. 121(29):e2404551121. doi: 10.1073/pnas.2404551121 |
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2024 |
Cappelletto A, Alfi E, Volf N, Vu TVA, Bortolotti F, Ciucci G, Vodret S, Fantuz M, Perin M, Colliva A, Rozzi G, Rossi M, Ruozi G, Zentilin L, Vuerich R, Borin D, Lapasin R, Piazza S, Chiesa M, Lorizio D, Triboli L, Kumar S, Morello G, Tripodo C, Pinamonti M, Piperno GM, Benvenuti F, Rustighi A, Jo H, Piccolo S, Del Sal G, Carrer A, Giacca M, Zacchigna S. EMID2 is a novel biotherapeutic for aggressive cancers identified by in vivo screening. J Exp Clin Cancer Res. 43(1):15. doi: 10.1186/s13046-023-02942-4 |
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2024 |
Graham K, Lienau P, Bader B, Prechtl S, Naujoks J, Lesche R, Weiske J, Kuehnlenz J, Brzezinka K, Potze L, Zanconato F, Nicke B, Montebaur A, Bone W, Golfier S, Kaulfuss S, Kopitz C, Pilari S, Steuber H, Hayat S, Kamburov A, Steffen A, Schlicker A, Buchgraber P, Braeuer N, Font NA, Heinrich T, Kuhnke L, Nowak-Reppel K, Stresemann C, Steigemann P, Walter AO, Blotta S, Ocker M, Lakner A, von Nussbaum F, Mumberg D, Eis K, Piccolo S, Lange M. Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. Cell Chem Biol. S2451-9456(24)00087-4. doi: 10.1016/j.chembiol.2024.02.013 |
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2023 |
Piccolo S, Panciera T, Contessotto P, Cordenonsi M. YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches. Nat Cancer Jan;4(1):9-26. doi: 10.1038/s43018-022-00473-z. |
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2022 |
Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Nature 607: 790 |
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2022 |
Piccolo S, Sladitschek-Martens HL, Cordenonsi M. Mechanosignaling in vertebrate development. Dev Biol.Aug;488:54-67 |
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2022 |
Donzelli S, Cioce M, Sacconi A, Zanconato F, Daralioti T, Goeman F, Orlandi G, Di Martino S, Fazio VM, Alessandrini G, Telera S, Carosi M, Ciliberto G, Botti C, Strano S, Piccolo S, Blandino G. A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions. Mol Cancer. 21(1):152. |
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2021 |
Velletri T, Villa CE, Cilli D, Barzaghi B, Lo Riso P, Lupia M, Luongo R, López-Tobón A, De Simone M, Bonnal RJP, Marelli L, Piccolo S, Colombo N, Pagani M, Cavallaro U, Minucci S, Testa G. Single cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer. Cell Death Differ doi: 10.1038/s41418-021-00878-w |
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2021 |
Gandin A, Torresan V, Ulliana L, Panciera T, Contessotto P, Citron A, Zanconato F, Cordenonsi M, Piccolo S, Brusatin G. Broadly Applicable Hydrogel Fabrication Procedures Guided by YAP/TAZ-Activity Reveal Stiffness, Adhesiveness, and Nuclear Projected Area as Checkpoints for Mechanosensing. Adv Healthc Mater 2021; e2102276 |
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2021 |
Battilana, G., Zanconato, F., and Piccolo, S. (2021). Mechanisms of YAP/TAZ transcriptional control. Cell Stress 5, 167-172 |
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2021 |
Castellan M, Guarnieri A, Fujimura A, Zanconato F, Battilana G, Panciera T, Sladitschek HL, Contessotto P, Citron A, Grilli A, Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M, Piccolo S. Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma. Nat Cancer 2021;2(2):174-188 |
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2021 |
Della Chiara G, Gervasoni F, Fakiola M, Godano C, D'Oria C, Azzolin L, Bonnal RJP, Moreni G, Drufuca L, Rossetti G, Ranzani V, Bason R, De Simone M, Panariello F, Ferrari I, Fabbris T, Zanconato F, Forcato M, Romano O, Caroli J, Gruarin P, Sarnicola ML, Cordenonsi M, Bardelli A, Zucchini N, Ceretti AP, Mariani NM, Cassingena A, Sartore-Bianchi A, Testa G, Gianotti L, Opocher E, Pisati F, Tripodo C, Macino G, Siena S, Bicciato S, Piccolo S, Pagani M. Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ. Nat Commun 2021; 12:2340 |
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2020 |
Marigo I, Trovato R, Hofer F, Ingangi V, Desantis G, Leone K, De Sanctis F, Ugel S, Canè S, Simonelli A, Lamolinara A, Iezzi M, Fassan M, Rugge M, Boschi F, Borile G, Eisenhaure T, Sarkizova S, Lieb D, Hacohen N, Azzolin L, Piccolo S, Lawlor R, Scarpa A, Carbognin L, Bria E, Bicciato S, Murray PJ, Bronte V. Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages. Cancer Discov 2020;10(11):1758-1773 |
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2020 |
Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nat Mater 2020;19(7):797-806 |
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2020 |
Piccolo S. Linking cancer transcriptional addictions by CDK7 to YAP/TAZ. Genes Dev 2020; 34(1-2):4-6 |
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2020 |
Albrecht LV, Tejeda-Muñoz N, Bui MH, Cicchetto AC, Di Biagio D, Colozza G, Schmid E, Piccolo S, Christofk HR, De Robertis EM. GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery. Cell Rep 2020;32(4):107973 (2020). |
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2020 |
Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, Figlerowicz M, Gasser SM, Hubner N, Kjems J, Knoblich JA, Krabbe G, Lichter P, Linnarsson S, Marine JC, Marioni JC, Marti-Renom MA, Netea MG, Nickel D, Nollmann M, Novak HR, Parkinson H, Piccolo S, Pinheiro I, Pombo A, Popp C, Reik W, Roman-Roman S, Rosenstiel P, Schultze JL, Stegle O, Tanay A, Testa G, Thanos D, Theis FJ, Torres-Padilla ME, Valencia A, Vallot C, van Oudenaarden A, Vidal M, Voet T; LifeTime Community Working Groups. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587(7834):377-386 |
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2020 |
Kidiyoor GR, Li Q, Bastianello G, Bruhn C, Giovannetti I, Mohamood A, Beznoussenko GV, Mironov A, Raab M, Piel M, Restuccia U, Matafora V, Bachi A, Barozzi S, Parazzoli D, Frittoli E, Palamidessi A, Panciera T, Piccolo S, Scita G, Maiuri P, Havas KM, Zhou ZW, Kumar A, Bartek J, Wang ZQ, Foiani M. ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nat Commun 2020; 11(1):4828 |
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2019 |
Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S. Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17848-17857. doi: 10.1073/pnas.1908228116. |
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2019 |
Zanconato F, Cordenonsi M, Piccolo S. YAP and TAZ: a signalling hub of the tumour microenvironment. Nat Rev Cancer. 2019 Aug;19(8):454-464. doi: 10.1038/s41568-019-0168-y. |
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2018 |
Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M,
Piccolo S.
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature (2018) 563(7730):265-269. |
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2018 |
Brusatin G, Panciera T, Gandin A, Citron A,
Piccolo S.
Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour. Nat Mater. (2018) 17(12):1063-1075. |
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2018 |
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M,
Piccolo S.
Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med. (2018) 24(10):1599-1610. |
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2018 |
Totaro A, Panciera T,
Piccolo S.
YAP/TAZ upstream signals and downstream responses. Nat Cell Biol. (2018) 20(8):888-899. |
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2018 |
Panciera T, Azzolin L, Di Biagio D, Totaro A, Cordenonsi M,
Piccolo S.
De Novo Generation of Somatic Stem Cells by YAP/TAZ. J Vis Exp. (2018) 7;(135). |
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2018 |
Totaro A, Castellan M, Di Biagio D,
Piccolo S.
Crosstalk between YAP/TAZ and Notch Signaling. Trends Cell Biol. (2018) 28(7):560-573. |
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2018 |
Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S,
Piccolo S, Del Sal G.
Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis. Nat Cell Biol. (2018) 20(1):28-35. |
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2018 |
Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL,Guiu J, Alves MRP, Rundsten CF,Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ,
Piccolo S, Jensen KB.
YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell (2018) 22(1):35-49. |
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2017 |
Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M,
Piccolo S.
YAP/TAZ link cell mechanics to Notch signaling to control epidermal stem cell fate. Nat Commun (2017) 8:15206 |
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2017 |
Azzolin L and
Piccolo S.
A TIAM double hit to destruct YAP/TAZ. Cancer Cell (2017) 31(5):607-608 |
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2017 |
Panciera T, Azzolin L, Cordenonsi M,
Piccolo S.
Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol (2017) 18(12):758-770. |
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2016 |
Panciera T, Azzolin L, Fujimura A, Di Biagio D, Frasson C, Bresolin S, Soligo S, Basso G, Bicciato S, Rosato A, Cordenonsi M,
Piccolo S.
Induction of Exandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ. Cell Stem Cell. 2016 Sep 9. pii: S1934-5909(16)30256-9. doi: 10.1016/j.stem.2016.08.009. |
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2016 |
Zanconato F, Cordenonsi M,
Piccolo S.
YAP/TAZ at the Roots of Cancer. Cancer Cell 29, 783-803. |
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2016 |
Zanconato F, Battilana G, Cordenonsi M,
Piccolo S.
YAP/TAZ as therapeutic targets in cancer. Curr Opin Pharmacol. 29, 26-33. |
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2016 |
Nowell CS, Odermatt PD, Azzolin L, Hohnel S, Wagner EF, Fantner GE, Lutolf MP, Barrandon Y,
Piccolo S, Radtke F.
Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction. Nat Cell Biol. 18, 168-80. |
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2015 |
Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M,
Piccolo S.
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat Cell Biol.17, 1218-27. |
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2014 |
Piccolo S,
Twists of fate. Sci Am. 311, 74-81. |
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2014 |
Piccolo S, Dupont S, Cordenonsi M.
The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev. 94, 1287-312. |
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2014 |
Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A,
Piccolo S, Del Sal G.
Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol. 16, 357-66. |
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2014 |
Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, Fassina A, Cordenonsi M, Piccolo S. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell 1, 157-70. |
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2013 |
Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 5, 1047-59. |
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2012 |
Azzolin L, Zanconato F, Bresolin S, Forcato M, Basso G, Bicciato S, Cordenonsi M, Cordenonsi M, and Piccolo S (2012) Role of TAZ in Wnt signaling. Cell 7, 1443-56 |
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2012 |
Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S. Self-regulation of the head-inducing properties of the Spemann organizer. Proc Natl Acad Sci U S A. 18 38, 15354-9 |
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2012 |
Halder G, Dupont S, and Piccolo S (2012) Transduction of mechanical and cytoskeletal cues by Yap and TAZ. Nature Reviews in Molecular and Cell Biology 9, 591-600 |
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2012 |
Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M and Piccolo S (2012). Sharp1 suppresses breast cancer metastasis by promoting degradation of HIFs/hypoxia-inducible factors. Nature 487, 380-4 |
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2011 | Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M., Parenti A, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, and Piccolo S (2011). The Hippo Transducer TAZ Confers Cancer Stem Cell-related Traits on Breast Cancer Cells. Cell 147, 759-72 |
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2011 | Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, and Piccolo S (2011). USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 13, 1368-75 |
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2011 | Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Zanconato F, Le Digabel J, Forcato M, Elvassore N and Piccolo S (2011). Role of YAP/TAZ in mechanotransduction. Nature 474: 179-183 |
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2010 | Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S and Piccolo S (2010) A microRNA targeting Dicer for metastasis control. Cell 141, 1195-1207 |
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2010 | Morsut L, Enzo E, Aragona M, Soligo S, Dupont S, Bressan G, Chambon P, Losson R, and Piccolo S (2010). Negative control of Smad activity by Ectodermin/Tif1g patterns the mammalian embryo. Development 137, 2571-2578 |
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2010 | Inui M, Martello G and Piccolo S. (2010). microRNA control of signal transduction. Nature Reviews in Molecular Cell Biology 11, 252-63 |
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2010 | Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Parenti R, Rosato A, Bicciato S, Balmain A and Piccolo S. (2009) A mutant-p53/Smad complex opposes p63 to empower TGF-beta induced metastasis. Cell 137, 87-98 |
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2009 | Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello M, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena M, Argenton F, Newfield S and Piccolo S. (2009) FAM/USP9x, a deubiquitinating enzyme essential for TGF-beta signaling controls Smad4 monoubiquitination. Cell 136, 123-135 |
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2007 | Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O and Piccolo S. (2007) MicroRNA control of Nodal signalling. Nature 449:183-8 |
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2007 | Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S, and Piccolo S. (2007). Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation. Science 315:840-3. |
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2006 | Zacchigna, L.1, Vecchione, C., Notte, A., Cordenonsi1, M., Dupont1, S., Maretto1, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo#, S., Lembo, G., and G. M. Bressan# (2006). Emilin1, a cysteine-richglycoprotein of elastic fibers, is required for blood pressurehomeostasis by regulating TGF-? maturation (2006). Cell 124, 929-42 # corresponding author, 1 SP lab |
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2005 | Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. (2005). Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121, 87-99. |
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2003 | Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., and Piccolo, S. (2003). Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113, 301-314. |
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2003 | Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., and Piccolo, S. (2003). Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 100, 3299-3304. |
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