Primary Research Publications

2023
  Piccolo S, Panciera T, Contessotto P, Cordenonsi M. YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches. Nat Cancer Jan;4(1):9-26. doi: 10.1038/s43018-022-00473-z.



2022
  Sladitschek-Martens HL, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato RL, Panciera T, Forcato M, Bicciato S, Guzzardo V, Fassan M, Ulliana L, Gandin A, Tripodo C, Foiani M, Brusatin G, Cordenonsi M, Piccolo S. YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Nature Jul;607(7920):790-798. doi: 10.1038/s41586-022-04924-6.



2022
  Piccolo S, Sladitschek-Martens HL, Cordenonsi M. Mechanosignaling in vertebrate development. Dev Biol.Aug;488:54-67. doi: 10.1016/j.ydbio.2022.05.005.



2021
  Battilana, G., Zanconato, F., and Piccolo, S. (2021). Mechanisms of YAP/TAZ transcriptional control. Cell Stress 5, 167-172. 10.15698/cst2021.11.258.



2021
  Della Chiara, G., Gervasoni, F., Fakiola, M., Godano, C., D'Oria, C., Azzolin, L., Bonnal, R.J.P., Moreni, G., Drufuca, L., Rossetti, G., Piccolo S, Pagani M., et al. (2021). Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ. Nat Commun 12, 2340. 10.1038/s41467-021-22544-y.



2021
  Castellan, M., Guarnieri, A., Fujimura, A., Zanconato, F., Battilana, G., Panciera, T., Sladitschek, H.L., Contessotto, P., Citron, A., Grilli, A., Romano O, Bicciato S, Fassan M, Porcù E, Rosato A, Cordenonsi M and Piccolo S. (2021). Single-cell analyses reveal YAP/TAZ as regulators of stemness and cell plasticity in Glioblastoma. Nat Cancer 2, 174-188. 10.1038/s43018-020-00150-z.



2021
  Rajewsky, N., Almouzni, G., Gorski, S.A., Aerts, S., Amit, I., Bertero, M.G., Bock, C., Bredenoord, A.L., Cavalli, G., Chiocca, S., Piccolo S., et al. (2020). LifeTime and improving European healthcare through cell-based interceptive medicine. Nature 587, 377-386. 10.1038/s41586-020-2715-9.



2020
  Panciera T, Citron A, Di Biagio D, Battilana G, Gandin A, Giulitti S, Forcato M, Bicciato S, Panzetta V, Fusco S, Azzolin L, Totaro A, Dei Tos AP, Fassan M, Vindigni V, Bassetto F, Rosato A, Brusatin G, Cordenonsi M, Piccolo S. Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nat Mater. 2020 Feb 17. doi: 10.1038/s41563-020-0615-x.



2019
  Totaro A, Zhuang Q, Panciera T, Battilana G, Azzolin L, Brumana G, Gandin A, Brusatin G, Cordenonsi M, Piccolo S. Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17848-17857. doi: 10.1073/pnas.1908228116.



2019
  Zanconato F, Cordenonsi M, Piccolo S. YAP and TAZ: a signalling hub of the tumour microenvironment. Nat Rev Cancer. 2019 Aug;19(8):454-464. doi: 10.1038/s41568-019-0168-y.



2018
  Chang L, Azzolin L, Di Biagio D, Zanconato F, Battilana G, Lucon Xiccato R, Aragona M, Giulitti S, Panciera T, Gandin A, Sigismondo G, Krijgsveld J, Fassan M, Brusatin G, Cordenonsi M, Piccolo S. The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ. Nature (2018) 563(7730):265-269.



2018
  Brusatin G, Panciera T, Gandin A, Citron A, Piccolo S. Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour. Nat Mater. (2018) 17(12):1063-1075.



2018
  Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, Quaranta E, Di Biagio D, Sigismondo G, Guzzardo V, Lejeune P, Haendler B, Krijgsveld J, Fassan M, Bicciato S, Cordenonsi M, Piccolo S. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med. (2018) 24(10):1599-1610.



2018
  Totaro A, Panciera T, Piccolo S. YAP/TAZ upstream signals and downstream responses. Nat Cell Biol. (2018) 20(8):888-899.



2018
  Panciera T, Azzolin L, Di Biagio D, Totaro A, Cordenonsi M, Piccolo S. De Novo Generation of Somatic Stem Cells by YAP/TAZ. J Vis Exp. (2018) 7;(135).



2018
  Totaro A, Castellan M, Di Biagio D, Piccolo S. Crosstalk between YAP/TAZ and Notch Signaling. Trends Cell Biol. (2018) 28(7):560-573.



2018
  Ingallina E, Sorrentino G, Bertolio R, Lisek K, Zannini A, Azzolin L, Severino LU, Scaini D, Mano M, Mantovani F, Rosato A, Bicciato S, Piccolo S, Del Sal G. Mechanical cues control mutant p53 stability through a mevalonate-RhoA axis. Nat Cell Biol. (2018) 20(1):28-35.



2018
  Yui S, Azzolin L, Maimets M, Pedersen MT, Fordham RP, Hansen SL, Larsen HL,Guiu J, Alves MRP, Rundsten CF,Johansen JV, Li Y, Madsen CD, Nakamura T, Watanabe M, Nielsen OH, Schweiger PJ, Piccolo S, Jensen KB. YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration. Cell Stem Cell (2018) 22(1):35-49.



2017
  Totaro A, Castellan M, Battilana G, Zanconato F, Azzolin L, Giulitti S, Cordenonsi M, Piccolo S. YAP/TAZ link cell mechanics to Notch signaling to control epidermal stem cell fate. Nat Commun (2017) 8:15206



2017
  Azzolin L and Piccolo S. A TIAM double hit to destruct YAP/TAZ. Cancer Cell (2017) 31(5):607-608



2017
  Panciera T, Azzolin L, Cordenonsi M, Piccolo S. Mechanobiology of YAP and TAZ in physiology and disease. Nat Rev Mol Cell Biol (2017) 18(12):758-770.



2016
  Panciera T, Azzolin L, Fujimura A, Di Biagio D, Frasson C, Bresolin S, Soligo S, Basso G, Bicciato S, Rosato A, Cordenonsi M, Piccolo S. Induction of Exandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZ. Cell Stem Cell. 2016 Sep 9. pii: S1934-5909(16)30256-9. doi: 10.1016/j.stem.2016.08.009.



2016
  Zanconato F, Cordenonsi M, Piccolo S. YAP/TAZ at the Roots of Cancer. Cancer Cell 29, 783-803.



2016
  Zanconato F, Battilana G, Cordenonsi M, Piccolo S. YAP/TAZ as therapeutic targets in cancer. Curr Opin Pharmacol. 29, 26-33.



2016
  Nowell CS, Odermatt PD, Azzolin L, Hohnel S, Wagner EF, Fantner GE, Lutolf MP, Barrandon Y, Piccolo S, Radtke F. Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction. Nat Cell Biol. 18, 168-80.



2015
  Zanconato F, Forcato M, Battilana G, Azzolin L, Quaranta E, Bodega B, Rosato A, Bicciato S, Cordenonsi M, Piccolo S. Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth. Nat Cell Biol.17, 1218-27.



2014
  Piccolo S, Twists of fate. Sci Am. 311, 74-81.



2014
  Piccolo S, Dupont S, Cordenonsi M. The biology of YAP/TAZ: hippo signaling and beyond. Physiol Rev. 94, 1287-312.



2014
  Sorrentino G, Ruggeri N, Specchia V, Cordenonsi M, Mano M, Dupont S, Manfrin A, Ingallina E, Sommaggio R, Piazza S, Rosato A, Piccolo S, Del Sal G. Metabolic control of YAP and TAZ by the mevalonate pathway. Nat Cell Biol. 16, 357-66.



2014
  Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, Bresolin S, Frasson C, Basso G, Guzzardo V, Fassina A, Cordenonsi M, Piccolo S. YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response. Cell 1, 157-70.



2013
  Aragona M, Panciera T, Manfrin A, Giulitti S, Michielin F, Elvassore N, Dupont S, Piccolo S. A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors. Cell 5, 1047-59.



2012
  Azzolin L, Zanconato F, Bresolin S, Forcato M, Basso G, Bicciato S, Cordenonsi M, Cordenonsi M, and Piccolo S (2012) Role of TAZ in Wnt signaling. Cell 7, 1443-56



2012
  Inui M, Montagner M, Ben-Zvi D, Martello G, Soligo S, Manfrin A, Aragona M, Enzo E, Zacchigna L, Zanconato F, Azzolin L, Dupont S, Cordenonsi M, Piccolo S. Self-regulation of the head-inducing properties of the Spemann organizer. Proc Natl Acad Sci U S A. 18 38, 15354-9



2012
  Halder G, Dupont S, and Piccolo S (2012) Transduction of mechanical and cytoskeletal cues by Yap and TAZ. Nature Reviews in Molecular and Cell Biology 9, 591-600



2012
  Montagner M, Enzo E, Forcato M, Zanconato F, Parenti A, Rampazzo E, Basso G, Leo G, Rosato A, Bicciato S, Cordenonsi M and Piccolo S (2012). Sharp1 suppresses breast cancer metastasis by promoting degradation of HIFs/hypoxia-inducible factors. Nature 487, 380-4



2011   Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M., Parenti A, Poletti A, Daidone MG, Dupont S, Basso G, Bicciato S, and Piccolo S (2011). The Hippo Transducer TAZ Confers Cancer Stem Cell-related Traits on Breast Cancer Cells. Cell 147, 759-72



2011   Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, and Piccolo S (2011). USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 13, 1368-75



2011   Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Zanconato F, Le Digabel J, Forcato M, Elvassore N and Piccolo S (2011). Role of YAP/TAZ in mechanotransduction. Nature 474: 179-183



2010   Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, Parenti AR, Daidone MG, Bicciato S and Piccolo S (2010) A microRNA targeting Dicer for metastasis control. Cell 141, 1195-1207



2010   Morsut L, Enzo E, Aragona M, Soligo S, Dupont S, Bressan G, Chambon P, Losson R, and Piccolo S (2010). Negative control of Smad activity by Ectodermin/Tif1g patterns the mammalian embryo. Development 137, 2571-2578



2010   Inui M, Martello G and Piccolo S. (2010). microRNA control of signal transduction. Nature Reviews in Molecular Cell Biology 11, 252-63



2010   Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Parenti R, Rosato A, Bicciato S, Balmain A and Piccolo S. (2009) A mutant-p53/Smad complex opposes p63 to empower TGF-beta induced metastasis. Cell 137, 87-98



2009   Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello M, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena M, Argenton F, Newfield S and Piccolo S. (2009) FAM/USP9x, a deubiquitinating enzyme essential for TGF-beta signaling controls Smad4 monoubiquitination. Cell 136, 123-135



2007   Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O and Piccolo S. (2007) MicroRNA control of Nodal signalling. Nature 449:183-8



2007   Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S, and Piccolo S. (2007). Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation. Science 315:840-3.



2006   Zacchigna, L.1, Vecchione, C., Notte, A., Cordenonsi1, M., Dupont1, S., Maretto1, S., Cifelli, G., Ferrari, A., Maffei, A., Fabbro, C., Braghetta, P., Marino, G., Selvetella, G., Aretini, A., Colonnese, C., Bettarini, U., Russo, G., Soligo, S., Adorno, M., Bonaldo, P., Volpin, D., Piccolo#, S., Lembo, G., and G. M. Bressan# (2006). Emilin1, a cysteine-richglycoprotein of elastic fibers, is required for blood pressurehomeostasis by regulating TGF-? maturation (2006). Cell 124, 929-42 # corresponding author, 1 SP lab



2005   Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. (2005). Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121, 87-99.



2003   Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., and Piccolo, S. (2003). Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113, 301-314.



2003   Maretto, S., Cordenonsi, M., Dupont, S., Braghetta, P., Broccoli, V., Hassan, A. B., Volpin, D., Bressan, G. M., and Piccolo, S. (2003). Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc Natl Acad Sci U S A 100, 3299-3304.


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